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The endoplasmic reticulum (ER) is a multi-functional organelle and plays a crucial role in protein folding and lipid biosynthesis. Proteins synthesized in the ER are post-translationally modified via N- and O-glycosylation. The sec59 gene encodes a dolichol kinase that is required for N-glycosylation in the ER. Researchers interested in studying the role of sec59 created and characterized a sec59-1 deficient cell line.
